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Article

Risk of ovarian cancer in women with pelvic inflammatory disease and homologous recombination repair gene mutations under 55: a population-based cohort study.

Journal of gynecologic oncology - 1 Nov 2025

Feng Chenzhao, Luo Wanwan, Wang Zanhong, Cao Xi, Dong Chunlin, Li Fuxia, Xiao Rourou, Yang Bin, Chen Gang, Sun Chaoyang, Han Zhiqiang, Hao Xingjie, Wang Beibei

Abstract excerpt

OBJECTIVE: To address the relation among pelvic inflammatory disease (PID), genetic vulnerability and ovarian cancer (OC) risk, we assessed the association between PID and OC risk, alongside the interplay with germline homologous recombination repair (gHR) mutation, utilizing the UK Biobank. METHODS: We conducted a prospective cohort study in the UK Biobank by tracking OC incidences between individuals with and...

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Identifiers

PMID: 40517019
DOI: 10.3802/jgo.2025.36.e126
PMCID: PMC12636098

Genes

BRCA1
BRCA2
BRIP1
RAD51C
RAD51D

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