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Article

Anti-HMGCR myopathy: observed ethnic differences in disease and disease outcomes in New Zealand.

Rheumatology (Oxford, England) - 1 Nov 2025

Anderson Hamish, Chow Ke Li, O'Donnell John

Abstract excerpt

OBJECTIVES: Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy is an immune-mediated necrotizing myopathy strongly associated with statin use in adults. Polynesians have a higher incidence of anti-HMGCR myopathy in New Zealand (NZ), but ethnic differences in phenotype and outcome are not known. METHODS: Ninety-one patients with anti-HMGCR myopathy were identified based on anti-HMGCR positivity...

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Autoantibodies
Autoimmune Diseases
Creatine Kinase
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hydroxymethylglutaryl CoA Reductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscular Diseases

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Identifiers

PMID: 40515650
DOI: 10.1093/rheumatology/keaf338

Genes

HMGCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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