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Clinical phenotypes and long-term outcomes of anti-SRP versus anti-HMGCR immune-mediated necrotising myopathy: a 13-year single-centre study.

Clinical and experimental rheumatology - 1 Feb 2026

Clark Kristina E N, Clayton Lisa M, Thomas Rhys G, Kelly Stephen G, Walker Liz, Herrey Anna S, Dougan Ann, Patel Riyaz S, Fhadil Sadeer, Millner Thomas O, Marino Silvia, Radunovic Aleksandar

Abstract excerpt

OBJECTIVES: To characterise and compare the clinical phenotypes, malignancy risk, and long-term outcomes of anti-SRP and anti-HMGCR immune-mediated necrotising myopathy (IMNM). Given the rarity of this condition, we aimed to validate established findings within our large, ethnically diverse cohort managed over a 13-year period. METHODS: We conducted a retrospective, observational single-centre study of all...

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Identifiers

PMID: 41487111
DOI: 10.55563/clinexprheumatol/icqeff

Genes

HMGCR

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