Absence of Pathogenic Mutations and Strong Association With HLA-DRB1*11:01 in Statin-Naïve Early-Onset Anti-HMGCR Necrotizing Myopathy.

doi:10.1212/NXI.0000000000200285

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Article

Absence of Pathogenic Mutations and Strong Association With HLA-DRB1*11:01 in Statin-Naïve Early-Onset Anti-HMGCR Necrotizing Myopathy.

Neurology(R) neuroimmunology & neuroinflammation - 1 Sept 2024

Llansó Laura, Segarra-Casas Alba, Domínguez-González Cristina, Malfatti Edoardo, Kapetanovic Solange, Rodríguez-Santiago Benjamín, de la Calle Oscar, Blanco Rosa, Dobrescu Amelia, Nascimento-Osorio Andrés, Paipa Andrés, Hernandez-Lain Aurelio, Jou Cristina, Mariscal Anaís, González-Mera Laura, Arteche Ana, Lleixà Cinta, Caballero-Ávila Marta, Carbayo Álvaro, Vesperinas Ana, Querol Luis, Gallardo Eduard, Olivé Montse

Abstract excerpt

BACKGROUND AND OBJECTIVES: Immune-mediated necrotizing myopathy (IMNM) caused by antibodies against 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is an inflammatory myopathy that has been epidemiologically correlated with previous statin exposure. We characterized in detail a series of 11 young statin-naïve patients experiencing a chronic disease course mimicking a limb-girdle muscular dystrophy. With...

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PMID: 39106428
DOI: 10.1212/NXI.0000000000200285
PMCID: PMC11309561

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