Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel phenotypes of immune-mediated necrotizing myopathy identified independent of myositis-specific antibody specificity that improve prognostic stratification.

Frontiers in immunology - 1 Jan 2026

Wei Xiaojing, Sun Hui, Pang Zhidan, Bai Na, Guo Tiantian, Nie Changpu, Yang Xuan, Lu Zhen, Bao Liye, Miao Jing, Yu Xuefan

Abstract excerpt

Aim: To systematically investigate the clinical characteristics and prognosis of patients with immune-mediated necrotizing myopathy (IMNM), and to explore the proteomic landscape associated with different clinical phenotypes. Methods: A total of 133 IMNM patients were enrolled in this retrospective study. The clinical features and outcomes were compared across three subgroups: anti-HMGCR-positive,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Specificity
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers

Share to Muscle, Skeletal

Share to Muscular Diseases

Share to Myositis

Share to Necrosis

Share to Proteomics

Source

Open in PubMed Open full text

Identifiers

PMID: 42220524
DOI: 10.3389/fimmu.2026.1821033
PMCID: PMC13216009

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel phenotypes of immune-mediated necrotizing myopathy identified independent of myositis-specific antibody specificity that improve prognostic stratification.PMID 42220524Read ↗

Distinct phenotype and prognosis of immune-mediated necrotizing myopathy based on clinical-serological-pathological classification.Semantic proximity Read ↗

Clinical-pathologic classification of anti-HMGCR-positive immune-mediated necrotizing myopathySemantic proximity Read ↗

Performance of the 2017 European Alliance of Associations for Rheumatology/American College of Rheumatology Classification Criteria for Idiopathic Inflammatory Myopathies in Patients With Myositis-Specific Autoantibodies.Semantic proximity Read ↗

Classification of myositis.Semantic proximity Read ↗

Clinical phenotypes and long-term outcomes of anti-SRP versus anti-HMGCR immune-mediated necrotising myopathy: a 13-year single-centre study.Semantic proximity Read ↗

Integrated classification of inflammatory myopathiesSemantic proximity Read ↗

Clinical and histological features of immune-mediated necrotising myopathy: A multi-centre South Australian cohort study.Semantic proximity Read ↗

Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory MyopathiesSemantic proximity Read ↗

Clinical significance of myositis-specific autoantibodiesSemantic proximity Read ↗

Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis.Semantic proximity Read ↗

Deciphering the clinical presentations, pathogenesis, and treatment of the idiopathic inflammatory myopathies.Semantic proximity Read ↗

Clinical Characteristics of Immune-Mediated Necrotizing Myopathy with Autoantibodies Recognizing the Signal Recognition Particle: A Retrospective Study of a Chinese CohortSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.