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CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma

12 Jun 2025

Abstract excerpt

Despite the improvement, approximately 60% of patients with relapsed or refractory (r/r) aggressive B cell lymphoma (B-NHL) do not achieve durable benefit from CAR-T cell therapy. To elucidate factors associated with CAR-T therapy resistance, we conducted high-dimensional analyses of pre- and post-CAR-T cell specimens. In patients with non-durable response, we identified a prognostically relevant...

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PMID: 40513575
DOI: 10.1016/j.ccell.2025.05.013

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