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Article

Knockdown-resistance (kdr) mutations in Indian Aedes aegypti populations: Lack of recombination among haplotypes bearing V1016G, F1534C, and F1534L kdr alleles.

PLoS neglected tropical diseases - 1 Jun 2025

Kaur Taranjeet, Kushwah Rajababu S, Pradhan Sabyasachi, Das Manoj K, Kona Madhavinadha P, Anushrita, Mittal Radhika, Weetman David, Dixit Rajnikant, Singh Om P

Abstract excerpt

BACKGROUND: Knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) gene are a key mechanism of insecticide resistance in mosquitoes. In Asian Aedes aegypti populations two main VGSC haplogroups with kdr mutations have been identified: one carrying the F1534C mutation and another with V1016G and/or S989P mutations. Previous functional studies have demonstrated that these three mutations on...

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Topics

Animals
Aedes
Haplotypes
Insecticide Resistance
India
Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Voltage-Gated Sodium Channels

Mutation

Pyrethrins

Recombination, Genetic

Insecticides

Introns

Source

Open in PubMed Open full text

Identifiers

PMID: 40512720
DOI: 10.1371/journal.pntd.0013126
PMCID: PMC12165380

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