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Article

Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes aegypti.

PLoS neglected tropical diseases - 1 Apr 2020

Fan Yinjun, O'Grady Patrick, Yoshimizu Melissa, Ponlawat Alongkot, Kaufman Phillip E, Scott Jeffrey G

Abstract excerpt

BACKGROUND: Aedes aegypti is a globally distributed vector of human diseases including dengue, yellow fever, chikungunya, and Zika. Pyrethroid insecticides are the primary means of controlling adult A. aegypti populations to suppress arbovirus outbreaks, but resistance to pyrethroid insecticides has become a global problem. Mutations in the voltage-sensitive sodium channel (Vssc) gene are a major mechanism of...

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Identifiers

PMID: 32302303
DOI: 10.1371/journal.pntd.0008154
PMCID: PMC7164583

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