Article
Re-evaluation of MEFV carriers previously diagnosed with FMF: a colchicine discontinuation study.
Rheumatology (Oxford, England) - 1 Nov 2025
Cam Veysel, Unal Dilara, Sag Erdal, Bayindir Yagmur, Aliyev Emil, Emreol Hulya Ercan, Erkan Mehmet Orhan, Necipoglu Banak Ozlem, Dara Kar Hazel Delal, Basaran Ozge, Bilginer Yelda, Ozen Seza
Abstract excerpt
OBJECTIVES: FMF is an autoinflammatory disease associated with mutations in the MEFV gene. While typically inherited in an autosomal recessive pattern, heterozygous individuals may also exhibit FMF symptoms, often with a milder disease course. The long-term management of colchicine therapy in heterozygous patients, particularly decisions regarding its discontinuation, remains a clinical challenge. METHODS: This...
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