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Article

Machine-learning algorithms for predicting colchicine resistance in Familial Mediterranean Fever.

Rheumatology (Oxford, England) - 5 Mar 2026

Ozturk Admir, Kilic Berkay, Kucur Murad, Yagci Lara, Ugurlu Serdal

Abstract excerpt

OBJECTIVES: FMF is a genetic autoinflammatory condition marked by recurrent fever and serositis. Colchicine is the mainstay treatment. However, 5% to 10% of patients exhibit colchicine resistance, requiring alternative therapies. Early identification of resistance is vital. While some scoring systems exist for paediatric FMF, artificial intelligence's (AI's) potential to predict colchicine resistance in adult...

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Colchicine
Drug Resistance
Familial Mediterranean Fever
Logistic Models
Machine Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prediction Algorithms

Predictive Learning Models

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Identifiers

PMID: 41701173
DOI: 10.1093/rheumatology/keag096

Genes

MEFV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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