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Colchicine discontinuation in familial Mediterranean fever: short-term outcomes by pre-discontinuation attack frequency.

Clinical rheumatology - 1 Feb 2026

Aktas Berkay, Parlar Kerem, Senturk Burak, Saglam Alperen, Dundar Ata, Uc Ceren, Acar Beste, Ugurlu Serdal

Abstract excerpt

BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disorder associated with MEFV gene mutations. Recurrent febrile episodes associated with serosal inflammation, arthritis, and characteristic skin findings represent the classic presentation of FMF. Lifelong colchicine treatment is the standard of care. However, the feasibility of colchicine cessation in FMF remains controversial, with limited...

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Adolescent
Colchicine
Familial Mediterranean Fever
MEFV gene
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Treatment Outcome

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PMID: 41518583
DOI: 10.1007/s10067-025-07874-2

Genes

CRP
MEFV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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