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The role of whole-genome sequencing for guiding systemic therapy in patients with soft tissue sarcoma

1 Jun 2025

Abstract excerpt

BACKGROUND: The analysis of tumor DNA by whole-genome sequencing (WGS) is increasingly utilized for the identification of clinically relevant DNA aberrations. We aim to assess whether WGS improves the guidance of individualized systemic therapy in soft tissue sarcoma (STS). PATIENTS AND METHODS: WGS results of STS patients were retrieved from electronic patient records and pathology reports from clinical studies...

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PMID: 40505420
DOI: 10.1016/j.esmoop.2025.105287

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