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Article

Apatinib Promotes Ferroptosis in Colorectal Cancer Cells by Targeting ELOVL6/ACSL4 Signaling

1 Feb 2021

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a common digestive system malignancy. Ferroptosis, a new form of regulated cell death, plays a vital role in the pathogenesis and therapy of cancers. OBJECTIVE: We aimed to study the role of apatinib in ferroptosis of CRC cells and its potential mechanisms. MATERIALS AND METHODS: Human CRC HCT116 cells were exposed to apatinib. Cell viability was examined using a CCK-8 kit....

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PMID: 33603479
DOI: 10.2147/cmar.s274631

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