Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of mutations on MUC1-C/ED protein stability and antibody Binding: Structural insight.

Biochemical and biophysical research communications - 15 Aug 2025

Sanyal Dwipanjan, Muzata Danny, Uversky Vladimir N, Kharbanda Surender, Chowdhury Sourav, Jasuja Ravi

Abstract excerpt

Antibody-drug conjugates (ADCs) represent a transformative approach in cancer therapy, combining the specificity of monoclonal antibodies with targeted delivery of potent cytotoxic drugs to tumors. Discovery of novel antigens has been the hallmark for development of ADC therapeutics and MUC1 is one such oncoprotein, which has garnered renewed interest recently. The 3D1 antibody, engineered to bind specifically to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to MUC1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SEA gene

Share to Mucin-1

Share to Mutation

Share to Protein Binding

Share to Protein Domains

Share to Protein Stability

Source

Identifiers

PMID: 40499497
DOI: 10.1016/j.bbrc.2025.152114

Genes

MUC1
SEA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of mutations on MUC1-C/ED protein stability and antibody Binding: Structural insight.PMID 40499497Read ↗

Thermodynamic characterization of affinity maturation: the D1.3 antibody and a higher-affinity mutant.Semantic proximity Read ↗

Systematic mutation and thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions.Semantic proximity Read ↗

Principles of mucin structure: implications for the rational design of cancer vaccines derived from MUC1-glycopeptidesSemantic proximity Read ↗

Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational designSemantic proximity Read ↗

Engineering affinity of humanized ScFv targeting CD147 antibody: A combined approach of mCSM-AB2 and molecular dynamics simulations.Semantic proximity Read ↗

Insights into the stability of a therapeutic antibody Fab fragment by molecular dynamics and its stabilization by computational designSemantic proximity Read ↗

Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineeringSemantic proximity Read ↗

Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments.Semantic proximity Read ↗

Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations.Semantic proximity Read ↗

Energetic and dynamic aspects of the affinity maturation process: characterizing improved variants from the bevacizumab antibody with molecular simulations.Semantic proximity Read ↗

Structure of the MUC5AC VWD3 assembly responsible for the formation of net-like mucin polymers.Semantic proximity Read ↗

Hydrophobic core evolution of major histocompatibility complex class I chain-related protein A for dramatic enhancing binding affinity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.