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Article

Thermodynamic characterization of affinity maturation: the D1.3 antibody and a higher-affinity mutant.

Journal of molecular recognition : JMR - 1 Jan 1998

VanAntwerp J J, Wittrup K D

Abstract excerpt

Understanding the structural and dynamic determinants of binding free energy in the antigen-antibody bond is of great interest. Much work has focused on selective mutations in order to locate key interaction residues, but this generally results in reduced affinity. The present work instead examin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10076798
DOI: 10.1002/(SICI)1099-1352(199812)11:1/6<10::AID-JMR381>3.0.CO;2-H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10076798-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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