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Article

Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

21 Sept 2021

Abstract excerpt

Preadipocytes are crucial for healthy adipose tissue expansion. Preadipocyte differentiation is altered in obese individuals, which has been proposed to contribute to obesity-associated metabolic disturbances. Here, we aimed at identifying the pathogenic processes underlying impaired adipocyte differentiation in obese individuals with insulin resistance (IR)/type 2 diabetes (T2D). We report that down-regulation...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 34545810
DOI: 10.7554/elife.65996

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