Article

Autophagy flux during human aging is sex- and cell type-specific, and is associated with physical fitness

2026-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Autophagy is widely proposed to decline with age; however, direct evidence for this across cell and tissue types in humans remains limited. Furthermore, it remains unknown whether interventions that improve physiological health during aging can modify autophagic activity in humans. Here, we performed transcriptomic and functional autophagy analyses across subject-matched human cell types from a...

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Literature Corpus work: 6cbb8b4d-6027-5889-be3b-4bb48db5195d
DOI: 10.64898/2026.05.15.725565

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