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Trimethoprim resistance in Escherichia coli exhibits an allele-specific growth advantage

3 Jun 2025

Abstract excerpt

Introduction. The antibiotic trimethoprim has been used to treat urinary tract infection (UTI) since ~1962. Alongside the nitrofurantoin, there are still justified reasons for trimethoprim use, especially in non-pregnant women. Trimethoprim resistance is commonly the result of acquiring the trimethoprim-insensitive dihydrofolate reductase gene: dfrA. Assessment of clinical Escherichia coli isolates from two...

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PMID: 40459146
DOI: 10.1099/jmm.0.002021

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