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Article

Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection.

PloS one - 1 Jan 2022

Jakovljev Aleksandra, Afset Jan Egil, Haugum Kjersti, Steinum Harald Otto, Gresdal Rønning Torunn, Samuelsen Ørjan, Ås Christina Gabrielsen

Abstract excerpt

INTRODUCTION: Thymine auxotrophic in vitro mutants of Escherichia coli were first reported in the mid-20th century. Later, thymine-dependent clinical strains of E. coli as well as other Enterobacterales, Enterococcus faecalis and Staphylococcus aureus have been recognized as the cause of persistent and recurrent infections. OBJECTIVES: The aim of this study was to characterize the phenotype and investigate the...

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PMID: 35802671
DOI: 10.1371/journal.pone.0270256
PMCID: PMC9269972

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