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Article

Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline.

PLoS biology - 1 Sept 2022

Jagdmann Jennifer, Andersson Dan I, Nicoloff Hervé

Abstract excerpt

In a collection of Escherichia coli isolates, we discovered a new mechanism leading to frequent and high-level tigecycline resistance involving tandem gene amplifications of an efflux pump encoded by the tet(A) determinant. Some isolates, despite carrying a functional tet(A), could not evolve high-level tigecycline resistance by amplification due to the presence of a deletion in the TetR(A) repressor. This...

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Identifiers

PMID: 36170241
DOI: 10.1371/journal.pbio.3001808
PMCID: PMC9550176

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