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Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals

2 Jun 2025

Abstract excerpt

Genomic imprinting is manifested as monoallelic expression of genes according to parental origin, which is closely linked to mammalian placentation and human diseases. Yet, it is unclear how genomic imprinting evolves in different cell types. Here we generate a single-nucleus transcriptomic landscape of mammalian placental development, identifying 5 major cell types and 14 trophoblast subtypes. By developing a...

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Share to Epigenetics and DNA Methylation
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PMID: 40456771
DOI: 10.1038/s41467-025-60469-y

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