Article
Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics.
Journal of virology - 1 Sept 2012
McDonald Sarah M, McKell Allison O, Rippinger Christine M, McAllen John K, Akopov Asmik, Kirkness Ewen F, Payne Daniel C, Edwards Kathryn M, Chappell James D, Patton John T
Abstract excerpt
Group A rotaviruses (RVs) are 11-segmented, double-stranded RNA viruses and are primary causes of gastroenteritis in young children. Despite their medical relevance, the genetic diversity of modern human RVs is poorly understood, and the impact of vaccine use on circulating strains remains unknown. In this study, we report the complete genome sequence analysis of 58 RVs isolated from children with severe diarrhea...
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