Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.

doi:10.1371/journal.pgen.1006597

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Article

Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.

PLoS genetics - 1 Apr 2017

Duchesne Amandine, Vaiman Anne, Castille Johan, Beauvallet Christian, Gaignard Pauline, Floriot Sandrine, Rodriguez Sabrina, Vilotte Marthe, Boulanger Laurent, Passet Bruno, Albaric Olivier, Guillaume François, Boukadiri Abdelhak, Richard Laurence, Bertaud Maud, Timsit Edouard, Guatteo Raphaël, Jaffrézic Florence, Calvel Pierre, Helary Louise, Mahla Rachid, Esquerré Diane, Péchoux Christine, Liuu Sophie, Vallat Jean-Michel, Boichard Didier, Slama Abdelhamid, Vilotte Jean-Luc

Abstract excerpt

Neuropathies are neurodegenerative diseases affecting humans and other mammals. Many genetic causes have been identified so far, including mutations of genes encoding proteins involved in mitochondrial dynamics. Recently, the "Turning calves syndrome", a novel sensorimotor polyneuropathy was described in the French Rouge-des-Prés cattle breed. In the present study, we determined that this hereditary disease...

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PMID: 28376083
DOI: 10.1371/journal.pgen.1006597
PMCID: PMC5380314

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