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Emerging strategies to overcome PARP inhibitors' resistance in ovarian cancer

1 Nov 2024

Abstract excerpt

The utilization of PARP inhibitors (PARPis) has significantly improved the prognosis for ovarian cancer patients. However, as the use of PARPis increases, the issue of PARPi resistance has become more prominent. Prolonged usage of PARPis can lead to the development of resistance in ovarian cancer, often mediated by mechanisms such as homologous recombination (HR) recovery, ultimately resulting in cancer relapse....

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PMID: 39571765
DOI: 10.1016/j.bbcan.2024.189221

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