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Elevated Oxidative Stress and DNA Damage in Cortical Neurons of Chemotherapy Patients

1 Jul 2021

Abstract excerpt

The unintended neurologic sequelae of chemotherapy contribute to significant patient morbidity. Chemotherapy-related cognitive impairment (CRCI) is observed in up to 80% of cancer patients treated with chemotherapy and involves multiple cognitive domains including executive functioning. The pathophysiology underlying CRCI and the neurotoxicity of chemotherapy is incompletely understood, but oxidative stress and...

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PMID: 34363676
DOI: 10.1093/jnen/nlab074

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