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Combined analysis of somatic mutations and gene expression reveals nuclear speckles-associated enhanced stemness in gingivobuccal carcinoma under DNA damage response.

Computational biology and chemistry - 1 Dec 2025

Kumar Sachendra, De Tamasa, Subramani Janavi, Rangarajan Annapoorni, Pal Debnath

Abstract excerpt

Smokeless tobacco chewing habits in India lead to a high prevalence of Gingivobuccal oral squamous cell carcinoma (OSCC-GB). Cancer stem cells (CSCs) are a sub-population of cancer cells within a tumor with stem-like properties and are believed to contribute to tumor initiation, progression, increased resistance to drug therapy, and promote post-therapeutic cancer relapse. An RNA-sequencing data-based combined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40424937
DOI: 10.1016/j.compbiolchem.2025.108513

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SON

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