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Article

Genomic Insights into Oral Cancer Highlight Mutant SIGMAR1 as a Critical Target to Overcome Chemoresistance.

Biochemical genetics - 1 Apr 2026

Chagas Pablo Shimaoka, Garcia Cristiana Bernadelli, Leopoldino Andréia Machado

Abstract excerpt

Oral cancer (OC) is a highly aggressive malignancy characterized by uncontrolled cell proliferation in the oral cavity. Recent studies have highlighted the role of Sigma-1 receptor (SIGMAR1) mutations in cancer progression, disrupting cellular homeostasis, altering gene and protein expression, and promoting drug resistance. However, its role in OC remains scarce. This study investigated SIGMAR1 mutations,...

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Share to Antineoplastic Agents
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Drug Resistance, Neoplasm

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Source

Identifiers

PMID: 40257692
DOI: 10.1007/s10528-025-11108-0

Genes

SIGMAR1
SI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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