Partial s antigen expression in GP(B-A-B) hybrid glycophorins and the corresponding in vitro expression study.

doi:10.2450/BloodTransfus.1003

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Article

Partial s antigen expression in GP(B-A-B) hybrid glycophorins and the corresponding in vitro expression study.

Blood transfusion = Trasfusione del sangue - 1 Jan 2025

Wei Ling, Zhu Siying, Wen Jizhi, Liao Zhijian, Jia Shuangshuang, Ji Yanli

Abstract excerpt

BACKGROUND: The s antigen expression is mainly determined by a single nucleotide polymorphism at c.143C (p.Thr48) on the exon 4 of GYPB gene. Several mutations on the GYPB gene have been reported to cause aberrant s antigen expression. GP.Mur has an extra 31-amino acid insertion encoded by the active compound GYP(B-A) exon 3, which closely locates at the upstream of p.Thr48. It has been reported to cause altered...

Topics

Humans
Glycophorins
HEK293 Cells
Erythrocytes
Alleles
Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40423591
DOI: 10.2450/BloodTransfus.1003
PMCID: PMC12274195

Genes

GYPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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