Article
Genotyping analysis of MNS blood group GP(B-A-B) hybrid glycophorins in the Chinese Southern Han population using a high-resolution melting assay.
Transfusion - 1 Jul 2018
Wei Ling, Lopez Genghis H, Zhang Yang, Wen Jizhi, Wang Zhen, Fu Yongshui, Hyland Catherine A, Flower Robert L, Luo Guangping, Ji Yanli
Abstract excerpt
BACKGROUND: MNS hybrid GP(B-A-B) glycophorins are more commonly found in Southeast Asians and alloantibodies to antigens they carry are clinically significant. Detection of hybrid glycophorins by serologic techniques is limited due to lack of commercial reagents. In this study, a genotyping method for GP(B-A-B) hybrid glycophorins based on high-resolution melting (HRM) analysis was applied for genotyping analysis...
Topics
- Asian People
- Genotype
- Genotyping Techniques
- Glycophorins
- Heterozygote
- Homozygote
- Humans
- MNSs Blood-Group System
- Phenotype
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA