Article
The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB.
Transfusion - 1 Feb 2001
Storry J R, Reid M E, MacLennan S, Lubenko A, Nortman P
Abstract excerpt
BACKGROUND: GPB carries 'N' at its N:-terminus and S and s, determined by a polymorphism at amino acid position 29 (Met29Thr). The low-incidence antigens M(v), s(D), and Mit are associated with weakened expression of S and/or s, and the purpose of this study was to define their molecular bases. METHODS: The GPB gene (GYPB) was sequenced after RT-PCR of RNA from four samples: two M(v)+, one s(D)+, and one Mit+....
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