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Article

Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes.

Frontiers in immunology - 1 Jan 2025

Paktinat Shahrokh, Gravett Michael G, Tobey Cara, Kirby Anna, Horner Whitney, Shaffer Rebecca, Fialkow Michael, Nguyen Nam Phuong, Gornalusse Germán G, Kalatehjari Maryam, Hughes Sean M, Hladik Florian, Vojtech Lucia

Abstract excerpt

Introduction: The regulation of immune responses to promote tolerance to the fetus is critical for successful pregnancy. An understudied aspect of this process is the initiation of regulation pre-conception via exposure to semen. Our study aimed to understand how semen impacts recipient dendritic cells (DCs) and their subsequent role in shaping CD4 T cell differentiation. Methods: Monocyte-derived DCs (MoDCs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40421022
DOI: 10.3389/fimmu.2025.1564002
PMCID: PMC12104210

Genes

CD4
CD38
FOXP3
TIGIT

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