Article
Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy-Supportive Phenotype In Vitro.
European journal of immunology - 1 Sept 2025
Dietz-Ziegler Stefanie, Kewitz Samantha, Kaiser Gabriele, Rühle Jessica, Marmé Alexander, Dalpke Alexander, Cheaib Bachar, Pauluschke-Fröhlich Jan, Henes Melanie, Velic Ana, Pich Andreas, Vollert Anneli, Schaller Martin, Knab Felix, Lajqi Trim, Poets Christian F, Gille Christian, Köstlin-Gille Natascha
Abstract excerpt
Pregnancy requires immune tolerance to a semi-allogeneic fetus, involving profound adaptations, particularly in the T helper (Th) cell response. The intestinal microbiome plays a crucial role in health, but its influence on immune adaptation to pregnancy remains unclear. Bacterial extracellular vesicles (BEVs), released by gut bacteria, can cross the intestinal barrier and modulate immune responses. In our study...
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