Fetal sex shapes maternal immune adaptation: placental extracellular vesicles differentially reprogram the phenotype, metabolism, and function of circulating monocytes.

doi:10.3389/fimmu.2026.1855111

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Article

Fetal sex shapes maternal immune adaptation: placental extracellular vesicles differentially reprogram the phenotype, metabolism, and function of circulating monocytes.

Frontiers in immunology - 1 Jan 2026

Avalos Julieta, Sabbione Florencia, Rios Daiana, Grasso Daniel H, Garcia M Noe, Aguilera Franco, Merech Fatima, Aiello Horacio, Meller Cesar, Ramhorst Rosanna, Hauk Vanesa, Gori Soledad, Leirós Claudia Pérez, Vota Daiana M, Paparini Daniel E

Abstract excerpt

Introduction: Maternal immune adaptation during pregnancy is orchestrated by dynamic signals from the uterine microenvironment, including placental extracellular vesicles (pEVs) released into maternal circulation. EVs have emerged as key mediators of this crosstalk; however, their role in sex-specific immune modulation remains incompletely defined. Here, we investigated whether pEVs derived from term placentas...

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Topics

Humans
Female
Pregnancy
Extracellular Vesicles
Monocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Placenta

Phenotype

Adult

Adaptation, Physiological

Reactive Oxygen Species

Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42539792
DOI: 10.3389/fimmu.2026.1855111
PMCID: PMC13424588

Genes

CD14
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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