Article
Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA.
Cancer discovery - 4 Sept 2025
Wang Yuxuan, Joshu Corinne E, Curtis Samuel D, Douville Christopher, Burk Vernon A, Ru Meng, Popoli Maria, Ptak Janine, Dobbyn Lisa, Silliman Natalie, Coresh Josef, Boerwinkle Eric, Prizment Anna, Bettegowda Chetan, Kinzler Kenneth W, Papadopoulos Nickolas, Platz Elizabeth A, Vogelstein Bert
Abstract excerpt
To explore how early cancers can be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities study, including 26 participants diagnosed with cancer and 26 matched controls. At the index time point, 8 of these 52 participants scored positively with a multicancer early detection test. All eight participants were diagnosed...
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