Article
Sequence diversity lost in early pregnancy.
Nature - 1 Jun 2025
Arnadottir Gudny A, Jonsson Hakon, Hartwig Tanja Schlaikjær, Gruhn Jennifer R, Møller Peter Loof, Gylfason Arnaldur, Westergaard David, Chan Andrew Chi-Ho, Oddsson Asmundur, Stefansdottir Lilja, Roux Louise le, Steinthorsdottir Valgerdur, Swerford Moore Kristjan H, Olafsson Sigurgeir, Olason Pall I, Eggertsson Hannes P, Halldórsson Gísli H, Walters G Bragi, Stefansson Hreinn, Gudjonsson Sigurjon A, Palsson Gunnar, Jensson Brynjar O, Fridriksdottir Run, Petersen Jesper Friis, Helgason Agnar, Norddahl Gudmundur L, Rohde Palle Duun, Saemundsdottir Jona, Magnusson Olafur Th, Halldorsson Bjarni V, Bliddal Sofie, Banasik Karina, Gudbjartsson Daniel F, Nyegaard Mette, Sulem Patrick, Thorsteinsdottir Unnur, Hoffmann Eva R, Nielsen Henriette Svarre, Stefansson Kari
Abstract excerpt
Every generation, the human genome is shuffled during meiosis and a single fertilized egg gives rise to all of the cells of the body1. Meiotic errors leading to chromosomal abnormalities are known causes of pregnancy loss2,3, but genetic aetiologies of euploid pregnancy loss remain largely unexplained4. Here we characterize sequence diversity in early pregnancy loss through whole-genome sequencing of 1,007 fetal...
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