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Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss

23 Nov 2023

Abstract excerpt

Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The prevalence of these abnormalities and the allocation of (ab)normal cells in embryonic and placental lineages during intrauterine development remain elusive. In this study, we analyzed 1,745 spontaneous pregnancy losses and found that roughly half (50.4%) of the products of conception (POCs) were karyotypically abnormal, with...

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PMID: 37996709
DOI: 10.1038/s41591-023-02645-5

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