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Article

Genome-Wide Association Study of Age-Related Hearing Loss in CFW Mice Identifies Multiple Genes and Loci, Including Prkag2.

Journal of the Association for Research in Otolaryngology : JARO - 1 Aug 2025

Polesskaya Oksana, Boussaty Ely, Cheng Riyan, Lamonte Olivia A, Zhou Thomas Y, Du Eric, Sanches Thiago Missfeldt, Nguyen Khai-Minh, Okamoto Mika, Palmer Abraham A, Friedman Rick

Abstract excerpt

PURPOSE: Age-related hearing loss (ARHL) is one of the most prevalent conditions affecting the elderly. ARHL is influenced by a combination of environmental and genetic factors; the identification of the genes that confer risk will aid in the prevention and treatment of ARHL. The mouse and human inner ears are functionally and genetically homologous. We used Carworth Farms White (CFW) mice to study the genetic...

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PMID: 40399499
DOI: 10.1007/s10162-025-00994-1
PMCID: PMC12411389

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ABR

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