Obesity-induced adipocytes promote diabetes mellitus by regulating β islet cell function through exosome miR-138-5p

Abstract excerpt

Insulin dysfunction can lead to type 1 diabetes mellitus (T1DM), inducing an increase in blood glucose levels. Unfortunately, there remains a need for more effective clinical treatments for DM. Obesity is closely associated with islet dysfunction, but these inside mechanisms remain unclear. We indicated that obesity-induced adipocytes inhibit insulin secretion (IS) from β islet cells (β-cells) by elevating the...

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