Article

Skeletal muscle-derived exosomal miR-146a-5p inhibits lipogenesis by mediating muscle-fat axis and targeting GDF5-PPARγsignaling

2022-09-21

Abstract excerpt

<title>Abstract</title><p>Skeletal muscle-Fat interaction is essential for maintaining organismal energy homeostasis and managing obesity by secreting cytokines and exosomes, but the role of the latter as new mediator in the inter-tissue communication still remains unclear. Recently, we discovered that miR-146a-5p was mainly enriched in skeletal muscle-derived exosomes (SKM-Exos), more 50-fold higher than fat exos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c98d59de-7eb2-5bcf-be66-23e5604ea8bb
DOI: 10.21203/rs.3.rs-2041307/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Skeletal muscle-derived exosomal miR-146a-5p inhibits lipogenesis by mediating muscle-fat axis and targeting GDF5-PPARγsignalingDOI 10.21203/rs.3.rs-2041307/v1Read

Comparative Analysis of MicroRNA Expression Profiles Between Skeletal Muscle- and Adipose-Derived Exosomes in PigSemantic proximity Read

Obesity reprograms adipose extracellular vesicles to induce muscle atrophy via miR-150-5p-mediated transcriptional silencingSemantic proximity Read

Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageingSemantic proximity Read

Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2Semantic proximity Read

miR-196a-5p and miR-342-3p mediate skeletal muscle and thermogenic adipose tissue crosstalk through extracellular vesiclesSemantic proximity Read

Current understanding of the role of microRNAs from adipose-derived extracellular vesicles in obesitySemantic proximity Read

Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browningSemantic proximity Read

Extracellular miRNAs as mediators of obesity‐associated diseaseSemantic proximity Read

microRNAs regulate adipocyte differentiationSemantic proximity Read

Genetic regulation of exosome biogenesis pathway in human adipose and muscle tissue and association with obesity and insulin resistanceSemantic proximity Read

Colorectal cancer prompted adipose tissue browning and cancer cachexia through transferring exosomal miR‐146b‐5pSemantic proximity Read

Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic DysfunctionSemantic proximity Read