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A GLP1R gene variant and sex influence the response to semaglutide treatment in patients with severe obesity

19 May 2025

Abstract excerpt

OBJECTIVE: The objective of this study is to identify whether the glucagon-like peptide-1 receptor (GLP1R) gene variant rs6923761G→A has an influence on semaglutide response in individuals with severe obesity. METHODS: ). RESULTS: The frequency of the rs6923761 AA variant was 9 out of 112 patients (8%), GA was 42 out of 112 (37.5%), and GG was 61 out of 112 (54.5%). The mean weight loss kinetics was 1.64% (SD...

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PMID: 40384505
DOI: 10.1002/oby.24300

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