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Article

Self-authenticating genomic materials in Escherichia coli via advanced genome signatures.

Communications biology - 16 May 2025

Wang Zhaoguan, Cui Jingsong, Liu Qian, Li Jiawei, Guo Chi, Liu Yiyang, Jiang Changyue, Xue Hui, Li Jiaojiao, Ke Yonggang, Qi Hao

Abstract excerpt

The authenticity and integrity of synthetic genomic materials containing valuable intellectual property are essential for advancing scientific knowledge and enhancing biosafety. Nevertheless, existing DNA tags and watermarks have limited efficacy due to low mutation tolerance and inadequate digital encoding capacity. Here, we present "Genome Signature", a biochemically stable and tamper-resistant DNA labeling...

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Topics

Escherichia coli
Genome, Bacterial
Genomics
Synthetic Biology
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40379889
DOI: 10.1038/s42003-025-08171-z
PMCID: PMC12084327

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