Pathogenic Variants and Allele Loss of the NF2 and LZTR1 Gene in Sporadic Vestibular Schwannoma

Abstract excerpt

Background/Aim: Pathogenic variants and allele-loss of the NF2 gene with Merlin loss as consequence is the driving genetic event for vestibular schwannoma development. Our knowledge about the pathogenic NF2 variants in sporadic vestibular schwannoma is insufficient. Therefore, we analyzed a cohort of sporadic vestibular schwannomas by panel-sequencing. Patients and Methods: Forty-one sporadic vestibular...

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