Article
Uncommon HLA alleles identified by hemizygous ultra-high Sanger sequencing: haplotype associations and reconsideration of their assignment in the Common and Well-Documented catalogue.
Human immunology - 1 Feb 2016
Voorter Christina E M, Groeneweg Mathijs, Groeneveld Lisette, Tilanus Marcel G J
Abstract excerpt
Although the number of HLA alleles still increases, many of them have been reported being uncommon. This is partly due to lack of full length gene sequencing, especially for those alleles belonging to an allele ambiguity in which the first discovered allele has been assigned as the most frequent one. As members of the working group on Common and Well Documented (CWD) alleles and since we implemented full length...
Topics
- Alleles
- Gene Frequency
- Genotype
- HLA Antigens
- Haplotypes
- Hemizygote
- Histocompatibility Testing
- Humans
- Polymorphism, Genetic
- Sequence Analysis, DNA