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Article

A Hot-Swappable Genetic Switch: Building an Inducible and Trackable Functional Assay for the Essential Gene MEDIATOR 21.

ACS synthetic biology - 20 Jun 2025

Watson Isabella J, Maranas Cassandra, Nemhauser Jennifer L, Leydon Alexander R

Abstract excerpt

Essential genes, estimated to be approximately 20% of the Arabidopsis genome, are broadly expressed and required for reproductive success. They are difficult to study, as interfering with their function leads to premature death. Transcription is one of the essential functions of life, and the multiprotein Mediator complex coordinates the regulation of gene expression at nearly every eukaryotic promoter. In this...

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Identifiers

PMID: 40340410
DOI: 10.1021/acssynbio.5c00085
PMCID: PMC12911314

Genes

MED21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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