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Article

Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis.

The Plant cell - 1 Dec 2017

Dolan Whitney L, Dilkes Brian P, Stout Jake M, Bonawitz Nicholas D, Chapple Clint

Abstract excerpt

The phenylpropanoid pathway is a major global carbon sink and is important for plant fitness and the engineering of bioenergy feedstocks. In Arabidopsis thaliana, disruption of two subunits of the transcriptional regulatory Mediator complex, MED5a and MED5b, results in an increase in phenylpropanoid accumulation. By contrast, the semidominant MED5b mutation reduced epidermal fluorescence4-3 (ref4-3) results in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29203634
DOI: 10.1105/tpc.17.00282
PMCID: PMC5757269

Genes

MED16
MED23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis.PMID 29203634Read ↗

Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant.Semantic proximity Read ↗

REF4 and RFR1, subunits of the transcriptional coregulatory complex mediator, are required for phenylpropanoid homeostasis in Arabidopsis.Semantic proximity Read ↗

Transcriptome Analysis of Four Arabidopsis thaliana Mediator Tail Mutants Reveals Overlapping and Unique Functions in Gene Regulation.Semantic proximity Read ↗

Functional metabolomics as a tool to analyze Mediator function and structure in plants.Semantic proximity Read ↗

Semidominant mutations in reduced epidermal fluorescence 4 reduce phenylpropanoid content in Arabidopsis.Semantic proximity Read ↗

Mediator subunit 3 regulates flowering and is required for the Abscisic acid response in Arabidopsis.Semantic proximity Read ↗

Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence.Semantic proximity Read ↗

Mediator subunit 17 regulates light and darkness responses in Arabidopsis plants.Semantic proximity Read ↗

Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1.Semantic proximity Read ↗

Natural alleles of Mediator subunit genes modulate plant height in chickpea.Semantic proximity Read ↗

Loss of FERULATE 5-HYDROXYLASE Leads to Mediator-Dependent Inhibition of Soluble Phenylpropanoid Biosynthesis in Arabidopsis.Semantic proximity Read ↗

The MED7 subunit paralogs of Mediator function redundantly in development of etiolated seedlings in Arabidopsis.Semantic proximity Read ↗

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