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Article

Pharmacogenomics and Pharmacokinetics of Aspirin in Preeclampsia Prevention.

Circulation research - 20 Jun 2025

Tlaye Kenean Getaneh, Woldeamanuel Gashaw Garedew, Wong Kenneth Chi-Yin, Chen Lu, Zheng Ruqun, So Pui Kin, Wang Xueqin, Nguyen-Hoang Long, Zhong Mei, So Hon Cheong, Leung Bo Wah, Huang Yu, Wang Yao, Poon Liona C, Wang Chi Chiu

Abstract excerpt

BACKGROUND: It has become evident that some women develop preeclampsia despite aspirin. This study aimed to examine how such aspirin nonresponsiveness develops in high-risk preeclampsia pregnancies by exploring the role of genetic polymorphisms and aspirin metabolism. METHODS: The study involved pregnant women who developed preeclampsia despite low-dose aspirin and those who did not. First, we conducted a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40329906
DOI: 10.1161/CIRCRESAHA.124.325699

Genes

GLYAT
CYP2E1
NAT2
UGT1A6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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