Article
The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure.
JCI insight - 9 Jun 2025
Cusick Matthew, Nair Viji, Fermin Damian, Hartman John, Beamish Jeffrey A, Sun Zeguo, Zhang Zhongyang, Otto Edgar, Menon Rajasree, Nadimidla Sudha, Demchuk Nicholas, Shaffer Kelly, Heeger Peter, Zhang Weija, Menon Madhav C, Kretzler Matthias, Wiggins Roger C, Naik Abhijit S
Abstract excerpt
INTRODUCTIONMaladaptive hypertrophy, podocyte stress, and depletion contribute to kidney function decline. Although insulin-like growth factor 1 (IGF-1) plays a key role in early hypertrophic responses in the single kidney state, its impact on kidney transplant (KTx) outcomes remains uncertain. This report tests the hypothesis that early IGF-1 exposure reduces KTx survival. METHODSPopulation datasets compared...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.