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Article

A Systematic Review of the Application of Graph Neural Networks to Extract Candidate Genes and Biological Associations.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2025

Saxena Ankita, Nixon Bridgette, Boyd Amelia, Evans James, Faraone Stephen V

Abstract excerpt

The development of high throughput technologies has resulted in the collection of large quantities of genomic and transcriptomic data. However, identifying disease-associated genes or networks from these data has remained an ongoing challenge. In recent years, graph neural networks (GNNs) have emerged as a promising analytical tool, but it is not well understood which characteristics of these models result in...

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PMID: 40317893
DOI: 10.1002/ajmg.b.33031
PMCID: PMC12335376

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