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Article

HiGLDP: a hierarchical graph neural network for predicting lncRNA-disease associations through multi-omic integration.

BMC biology - 20 Feb 2026

Wang Yongtian, Wang Zhiyuan, Wang Tao, Hu Jialu, You Zhuhong, Peng Jiajie

Abstract excerpt

BACKGROUND: Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in the pathogenesis of complex human diseases. Despite significant advances, identifying disease-associated lncRNAs remains challenging due to the vast noncoding transcriptome and the complexity of lncRNA interaction networks. RESULTS: We propose HiGLDP, a computational framework for predicting lncRNA-disease associations through the...

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PMID: 41715074
DOI: 10.1186/s12915-026-02557-z
PMCID: PMC13032502

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