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Article

Leveraging undecided cases in chart-reviewed phenotypes to enhance EHR-based association studies.

Journal of biomedical informatics - 1 Jun 2025

Jian Xinyao, Zhang Dazheng, Yu Zehao, Xu Hua, Bian Jiang, Wu Yonghui, Tong Jiayi, Chen Yong

Abstract excerpt

OBJECTIVES: In electronic health record (EHR)-based association studies, phenotyping algorithms efficiently classify patient clinical outcomes into binary categories but are susceptible to misclassification errors. The gold standard, manual chart review, involves clinicians determining the true disease status based on their assessment of health records. These clinicians-labeled phenotypes are labor-intensive and...

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Algorithms
Alzheimer Disease
Electronic Health Records
Phenotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40316004
DOI: 10.1016/j.jbi.2025.104839
PMCID: PMC12243065

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